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李成华

发布时间 :2016年06月10日 浏览量 :740

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李成华,博士,副教授

联系方式: 028-85418843,lichenghua_AT_scu.edu.cn(请把_AT_换成@)

学习及工作经历

2014.10至今:四川大学太阳集团城网址生长代谢与衰老研究中心,副教授

2013.10-2014.10:美国杜克大学医学院,访问学者

2012.7-2013.10:四川大学太阳集团城网址生长代谢与衰老研究中心,副教授

2010.8-2012.6:四川大学太阳集团城网址生长代谢与衰老研究中心,讲师

2006.9-2010.7:清华大学太阳集团城网址,博士

2003.8-2006.8:重庆医科大学基础医学院,助教、讲师

2000.9-2003.7:中南大学湘雅医学院医学遗传学国家重点实验室,硕士

1996.9-2000.7:兰州大学太阳集团城网址,学士

研究方向及兴趣

1.肿瘤发生:利用哺乳动物细胞和小鼠作为模式生物,主要研究p63蛋白及其调控因子在肿瘤发生、发展中的作用

2.金属代谢:利用酵母和哺乳动物细胞作为模式生物,研究铜、铁、锌等金属元素在细胞内代谢调控的分子机理

近年来发表的主要论文

1. Anning Han, Juan Li, Yimin Li, Yang Wang, Johann Bergholz, Yujun Zhang,Chenghua Li*, Zhi-Xiong Xiao*. p63α modulates c-Myc activity via direct interaction and regulation of MM1 protein stability.Oncotarget, 2016, in press. (*Corresponding author)

2. Chen J, Shi H, Qi J, Liu D, Yang Z,Li C*.JNK1 inhibits transcriptional and pro-apoptotic activity of TAp63γ.FEBS Lett. 2015, 589(23):3686-90.(*Corresponding author)

3. Li D#,Li C#, Wu M, Chen Q, Wang Q, Ren J, Zhang Y.PKCδ stabilizes TAp63 to promote cell apoptosis.FEBS Lett. 2015, 589(16):2094-9. (#Co-first author)

4.Chenghua Li, Zhi-Xiong Xiao. Regulation of p63 Protein Stability via Ubiquitin-Proteasome Pathway.BioMed Res Int, vol. 2014, 2014: 175721.

5.C Li*, DL Chang, Z Yang, J Qi, R Liu, H He, D Li, ZX Xiao*.Pin1 modulates p63aprotein stability in regulation of cell survival, proliferation and tumor formation.Cell Death and Disease, 2013, 4: e943. (*Corresponding author)

6. Qiongqiong Chen, Decai Li, Jian Ren,Chenghua Li*, Zhi-Xiong Xiao. MUC1 activates JNK1 and inhibits apoptosis under genotoxic stress.Biochemical and Biophysical Research Communications. 2013,440(1):179-183.(*Corresponding author)

7. Lihua Liu, Jin Qi, Zemin Yang, Lianghong Peng,Chenghua Li*.Low-affinity copper transporter CTR2 is regulated by copper-sensing transrciption factor Mac1p in Saccharomyces cerevisiae.Biochemical and Biophysical Research Communications. 2012,420(3):600-604.(*Corresponding author)

8. Jin Qi, Anning Han, Zemin Yang,Chenghua Li*.Metal-sensing transrciption factors Mac1p and Aft1p coordinately regulate vacuolar copper transporter CTR2 in Saccharomyces cerevisiae.Biochemical and Biophysical Research Communications. 2012, 423(2): 424-8.(*Corresponding author)

9. Xiaorong Li, Jing Chen, Yong Yi,Chenghua Li*, Yujun Zhang*. DNA damage down-regulatesDNp63aand induces apoptosis independent of wild type p53.Biochemical and Biophysical Research Communications. 2012, 423(2): 338-43.(*Corresponding author)

10.Chenghua Li, Juan Wang, Bing Zhou.The Metal Chelating and Chaperoning Effects of Clioquinol:Insights from Yeast Studies.Journal of Alzheimer’s Disease, 2010,21(4): 1249–1262.